DOI: https://doi.org/10.30978/UNJ2018-3-5

Подвійна роль мікроглії в патогенезі розсіяного склерозу

N. I. Lysyanyi

Анотація


Наведено сучасні дані літератури щодо імунозахисної, нейроцитотоксичної та нейропротекторної функції мікрогліальних клітин ЦНС. Проаналізовано гетерогенність цих клітин. Показано їх фізіологічну роль у здоровому організмі (захист від інфекційних збудників, контроль за діяльністю нейронів, фагоцитозом пошкоджених клітин мозку та агрегованих білків). Обговорено дані про нейротоксичну та демієлінізувальну дію активованих мікрогліальних клітин самостійно чи в кооперації з імунними клітинами при дегенеративних та автоімунних захворюваннях ЦНС, зокрема при розсіяному склерозі. Наведено дані літератури про протизапальну та ремієлінізувальну дію мікроглії та гуморальних чинників, які сприяють її нейропротекторній функції. Зроблено висновок, що мікроглії притаманні, окрім імунозахисних, нейропротекторні та нейротоксичні функції, які виявляються при автоімунній та дегенеративній патології ЦНС.


Ключові слова


мікрогліальні клітини; нервова система; розсіяний склероз; цитокіни; демієлінізація; ремієлінізація

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Посилання


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